PHARMACOLOGY

Pharmacotherapeutic Group: Anti-Oxidant

Pharmacodynamic properties:  Coenzyme Q10 (CoQ10) is a substance similar to a vitamin. It is found in every cell of the body. Your body makes CoQ10, and your cells use it to produce energy your body needs for cell growth and maintenance. It also functions as an antioxidant, which protects the body from damage caused by harmful molecules. CoQ10 is naturally present in small amounts in a wide variety of foods, but levels are particularly high in organ  such as heart, liver, and kidney, as well as beef, soy oil, sardines and peanuts. Coenzymes help enzymes work to digest food and perform other body processes, and they help protect the heart and skeletal muscles.

Pharmacokinetic properties: Because of its hydrophobicity and large molecular weight, absorption of dietary coenzyme Q10 is slow and limited. Solubilized coenzyme Q10 formulations show enhanced bioavailability with Tmax of approximately 6 hours and an elimination half-life of approximately 33 hours 

INDICATIONS  Adjuvant therapy in male infertility, cardiovascular diseases, statin therapy, diabetes mellitus Non alcoholic fatty liver disease, age related deficiencies

 DOSE: For known coenzyme Q-10 deficiency: 150 mg daily. For heart failure in adults: 100 mg per day divided into 2 or 3 doses. For reducing the risk of future cardiac events in patients with recent myocardial infarction: 120 mg daily in 2 divided doses. For high blood pressure: 120-200 mg per day divided into 2 doses. For infertility in men: 200-300 mg per day. For muscular dystrophy: 100 mg per

CONTRAINDICATIONS : Hypersensitivity

 ADVERSE DRUG REACTIONS  Serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

DRUG INTERACTIONS :  Coenzyme Q-10 might lower the effectiveness of some chemotherapy drugs.  Coenzyme Q-10 might lower blood pressure. It can increase the effects of medications used to lower blood pressure. By helping the blood clot, coenzyme Q-10 might decrease the effectiveness of warfarin and increase the risk of dangerous clots.

PRESENTATION

KYUTEN 100: Each box contains: 10 blister pack of 10 tablets per strip