Pharmacodynamic 

Febuxostat is a xanthine oxidase inhibitor which selectively inhibits xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine to uric acid thereby decreasing uric acid. At therapeutic concentration does not inhibit other enzymes involved in purine and pyrimidine synthesis.

Pharmacokinetics

• Absorption: ≥ 49 %
• Distribution: Protein Binding: 99.2 % (primarily to albumin)
• Metabolism: Extensively metabolized by conjugation via uridine diphosphate glucuronosyltransferase (UDPGT) enzyme system and oxidation via cytochrome P450 (CYP) system.
• Elimination: Eliminated by both hepatic and renal pathways

Indication

For the chronic management of hyperuricemia in patients with gout.

Dose

For Chronic Gout

Initial Dose: 40 mg OD

 Increased to 80 mg OD after 2 weeks if serum uric acid 

Gout flare prophylaxis of at least 6 months is recommended.

 Side Effects

Nausea, Arthralgia, Rash & Liver function abnormalities

 Pregnancy Category : C

 Contraindications

Contraindicated in patient being treated with azathioprine or mercaptopurine

 Warning & Precautions:

• History of Major Cardiovascular Disease A higher rate of cardiovascular thromboembolic events was observed in patients treated with febuxostat who has history of major cardiovascular disease. Monitor for signs and symptoms of MI and stroke
• Gout flares Increase in gout flares can be observed frequently during the initiation of febuxostat. In order to prevent this concurrent prophylactic treatment with an NSAID or colchicine is recommended
• Hepatic Effects Liver enzymes can be elevated significantly. Measure liver tests promptly in patients who report symptoms that may indicate liver injury, including fatigue, anorexia, right upper abdominal discomfort, dark urine or jaundice

Storage

Store below 25◦C

Missed Dose

• Take the missed dose as soon as you remember.
• Skip the missed dose if it is almost time for your next scheduled dose.
• Do not take extra medicine to make up the missed dose.

 Presentation:

• Febumin 40 Each box contains: 10 strips X 10 Tabs. ALU-ALU Packing
• Febumin 80 Each box contains: 10 strips X 10 Tabs. ALU-ALU Packing