TIME Pharmaceuticals : Touching Lives, Delivering Promises
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TIME Pharmaceuticals: Thrive For Effectiveness
Generic Name
Composition
Therapeutic Category
Division
Mecobalamin + Pregabalin
Mecobalamin 750 mcg + Pregabalin 75 mg Capsules
Nerve Supplement + Anti-Convulsant
NEXUS
Methylcobalamin is a form of vitamin B 12 which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells.
Pregabalin is an alpha 2 delta ligand which decreases the pain by modulating calcium channel activity of the nerve cells. Together, they relieve neuropathic pain
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Mecobalamin |
Pregabalin |
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Absorption: Bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa, and are then actively absorbed from the gastrointestinal tract.
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Absorption: Rapidly absorbed in GIT, Cmax= within 1.5 hr, Bioavailability= >90 %
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Distribution: Extensively bound to specific plasma proteins called transcobalamins. Diffuses across the placenta and also appears in breast milk. |
Distribution: Not bound to plasma proteins.Vss: 0.56L/kg.
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Elimination: Excreted in the bile, and undergoes extensive enterohepatic recycling; part of a dose is excreted in the urine, most of it in the first 8 hours; urinary excretion. |
Metabolism: Less than 2 % is metabolized |
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Elimination:About 98% is excreted via urine as unchanged drug |
Based on individual patient response and tolerability
Constipation, Drowsiness, Dry mouth and Dizziness
Mecobalamin + Pregabalin should not be prescribed to individuals who are allergic to Pregabalin and vitamin B12 supplements
