Time Pharmaceuticals

Generic Name

Composition

Therapeutic Category

Division

Silodosin

Silodosin 4mg Capsules

Silodosin 8mg Capsules

Alpha Blocker

COSMO

Brand Name: Urosil

Generic: Silodosin

Composition: Silodosin 4mg & 8mg Capsule

Therapeutic Category: Alpha blocker

Mechanism of action:

Silodosin is a selective antagonist of post-synaptic alpha-1 adrenoreceptors, which are located in the human prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. Blockade of these alpha-1 adrenoreceptors causes smooth muscle in these tissues to relax, resulting in an improvement in urine flow and a reduction in benign prostatic hyperplasia (BPH) symptoms.

Pharmacokinetics:

Absorption:	Bioavailability: 32%, T_max: 2.6 +/- 0.9hr, C_max (8mg dose): 62ng/ml
Distribution:	Vd: 49.5 L, protein-bound: 97%.
Metabolism:	through glucuronidation, alcohol and aldehyde dehydrogenase, and cytochrome P450 3A4 (CYP3A4) pathways.
Elimination:	T_1/2: 13 +/- 8 hr, CL: 10L/hr , Urine: 34.5% , Faeces: 54.9%

THERAPEUTIC INDICATIONS

Silodosin (Silodosin) is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).

Dosage and Administration:

Conditions	Dosage
Recommended dose	8mg once daily
Elderly patient	No dose adjustment is required
Renal impairment	4mg once daily in moderate renal impairment
Hepatic impairment	No dose adjustment is required

Urosil should be taken with food.

Side effects

Ejaculatory disorders, include retrograde ejaculation and anejaculation., orthostatic hypotension, nasal congestion, and diarrhea.

Presentation:

PRODUCT DETAILS