TIME Pharmaceuticals : Touching Lives, Delivering Promises
"स्वस्थ नेपाल हाम्रो अभियान; गुणस्तरीय औषधि हाम्रो पहिचान"
TIME Pharmaceuticals: Thrive For Effectiveness
Generic Name
Composition
Therapeutic Category
Division
Ampicillin + Cloxacillin
Ampicillin 250mg + Cloxacillin 250mg Capsules
Ampicillin 125mg + Cloxacillin 125mg/5ml Dry Syrup
Penicillin Antibiotic
TIME
| BRAND | COMPOSITION | DESCRIPTION |
|---|---|---|
| BROCLOX |
Ampicillin Trihydrate BP equivalent to Ampicillin 250mg Cloxacillin Sodium BP equivalent to Cloxacillin 250mg |
White to slightly yellowish blended powder filled in Hard Gelatin capsule (0 size) with 'yellow body and red cap. |
| BROCLOX DS |
Each 5 ml of the reconstituted suspension contains: Ampicillin Trihydrate BP equivalent to Ampicillin 125mg Cloxacillin Sodium BP equivalent to Cloxacillin 125mg |
Slight pink blended granules and powder filled in 78 ml overflow capacity amber coloured bottle with outer ring at 60 ml volume for reconstitution. |
PATIENT INFORMATION |
|---|
|
Food Interaction: Reduced absorption for ampicillin & delayed obsorption for cloxacillin Administration: May be taken with or without food.Taking it with a meal may however minimize stomach irritation, diarrhoea and nausea. Pregnancy:Category B Storage: Store below 25 °C Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. |
PHARMACOLOGY
Pharmacotherapeutic Group: Penicillin Antibiotics
Pharmacodynamic Properties:BROCLOX has bactericidal action. It inhibits the bacterial cell wall synthesis by interfering with transpeptidase enzyme. Ampicillin is bactericidal against non β- lactamase producing gram positive organisms and selected gram negative pathogens. Cloxacillin is a β lactamase resistant penicillin active against gram positive organisms including beta lactamase producing strains of Staphylococci.
INDICATIONS
Post Operative Infections, Bone and Joint infections, dental infections, osteomyelitis, SSTI, ENT infections, Gastroenteritis, RTI, Pneumonia, Gonorrhea
DOSAGE & ADMINISTRATION
Adult: Per capsule contains Ampicillin 250mg & Cloxacillin, one capsule four times daily.Child: Each 5ml dose contains ampicillin 125mg and cloxacillin 125mg. 5ml four times daily.
ADVERSE DRUG REACTIONS
GI upsets, rash, urticaria, neutropenia, neurotoxicity.
Potentially fatal: Anaphylactic reaction
PRECAUTIONS
Allergy to cephalosporins, infectious mononucleosis, neonates with jaundice, convulsions, lactation
DRUG INTERACTIONS
Failure of oral contraceptives, increased rash with allopurinol, reduced bactericidal activity with chloramphenicol, erythromycin and tetracyclines.
CONTRAINDICATIONS
Hypersensitivity to penicillins
PRESENTATION
BROCLOX: Each box contains 10 Strip of 10 Tablet per strip
BROCLOX D.S.: Each bottle contains 60ml Dry Syrup
