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Generic Name
Composition
Therapeutic Category
Division
Alprazolam 0.25
Alprazolam 0.25mg Tablet
Alprazolam 0.5mg Tablet
Anti-anxiety
GENESIS
| BRAND | COMPOSITION | DESCRIPTION |
|---|---|---|
| ZOLAP 0.25 |
Each uncoated tablet contains:
Alprazolam 0.25mg
|
Light green, round, biconvex tablet with breakline on one side and smooth surface on the other side. |
| ZOLAP 0.5 |
Each uncoated tablet contains:
Alprazolam 0.5mg
|
Light blue, round, biconvex tablet with breakline on one side and smooth surface on the other side. |
Pharmacotherapeutic Group: Anxiolytic agent
Pharmacodynamic properties: Alprazolam, like other benzodiazepines, has a high affinity for the benzodiazepine binding site in the brain. It binds to the the inhibitory neurotransmitter γ aminobutyric acid (GABA) throughout the CNS, which mediates both pre- and post synaptic inhibition in the central nervous system (CNS).This leads to an increase in the inhibitory effect of GABA on neuronal excitability due to increased neuronal permeability to chloride ions thus results in hyperpolarisation and stabilisation.
Pharmacokinetic properties: Absorption: Well absorbed from the GIT (oral); peak plasma concentrations after 1-2 hrs; Distribution: Protein-binding: 70-80% ; Metabolism: Hepatic; converted to α-hydroxyalprazolam and benzophenone; Excretion: Urine (as unchanged drug and metabolites); 11-15 hrs (elimination half-life).
INDICATIONS : Anxiety Disorder, Panic Disorder, Agoraphobia, Essential Tremors
DOSE : Short-term management of anxiety: 0.25-0.5 mg tid, increased to 3-4 mg daily if necessary.Elderly: Initially, 0.25 mg bid/tid.. Hepatic impairment: Avoid in severe impairment.Panic attacks: Up to 10 mg daily.
PATIENT INFORMATION |
|---|
Administration
Pregnancy Category: D Storage: Store below 25 °C. Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. |
CONTRAINDICATIONS : Acute narrow-angle glaucoma, preexisting CNS depression or coma, respiratory depression, acute pulmonary insufficiency or sleep apnoea; severe hepatic impairment; pregnancy, lactation.
SPECIAL PRECAUTIONS : Dosage reduction or gradual withdrawal. Dependence. Geriatric or debilitated patients. Muscle weakness, impaired hepatic or renal function; arteriosclerosis; obesity; depression particularly suicidal tendency; chronic pulmonary insufficiency.Children
ADVERSE DRUG REACTIONS : Psychological and physical dependence, withdrawal syndrome; drowsiness, sedation, vertigo, headache, visual disturbances, GI disturbances, jaundice; fatigue, muscle weakness, ataxia, dizziness, confusion and depression. Potentially Fatal: Blood dyscrasias.
DRUG INTERACTIONS : Potentiates action of alcohol and CNS depressants. Reduced conc with cigarette smoking by 50%. Potentially Fatal: Cimetidine and fluoxetine reduce the clearance of alprazolam. Alprazolam enhances activity of imipramine and desipramine
PRESENTATION
