Cefdinir 125mg Dispersible Tablets
Cefdinir 250mg Dispersible Tablets
Cefdinir 300mg Tablets
|DINIR 125mg|| Each dispersible tablet contains:
|DINIR 250mg||Each dispersible tablet contains:
|DINIR 300mg||Each tablet contains:
Cefdinir binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Oral Bioavailability: Maximal plasma cefdinir concentrations: 2 to 4 hours post-dose administration. Estimated bioavailability: 21%.
Effect of Food: Although the rate (Cmax) and extent (AUC) of cefdinir absorption are reduced by 16% and 10%, respectively, when given with a high-fat meal, the magnitude of these reductions is not likely to be clinically significant. Therefore, cefdinir can be taken before or after food.
Cefdinir is 60% to 70% bound to plasma proteins in both adult and pediatric subjects; binding is independent of concentration.
Metabolism and Excretion:
Cefdinir is not appreciably metabolized. Activity is primarily due to the parent drug. Cefdinir is eliminated principally via renal excretion with a mean plasma elimination half-life (t½) of 1.7 (±0.6) hours.
Patients with Renal Insufficiency: Dosage adjustment is recommended in patients with markedly compromised renal function.
Hepatic Disease: Because of renal eliminated and not appreciably metabolized, dosage adjustment will not be required in this population with hepatic impairment.
Geriatric Patients: Elderly patients do not require dosage adjustment unless they have markedly compromised renal function.
Acute Otitis Media caused by Haemophilus influenza or Moraxella catarrhalis (including β-lactamase producing strains), Streptococcus pneumoniae (penicillin-susceptible strain only)
Pharyngitis & Tonsillitis caused by Streptococcus pyogenes (Group A β-hemolytic streptococci)
Skin & Skin Structure Infections caused by Staphylococcus aureus (includingβ-lactamase producing strains) or pyogenes.
Diarrhea, nausea, chills, black stools, stomach pain, indigestion, oral thrush, abdominal pain, vaginitis itching, discharge, etc.
Concomitant administration with antacids and iron reduces the rate and extent of absorption. Probenecid reduces renal elimination.
Known allergy to the cephalosporin class of antibiotics.
Strips of 10 ×10 Tablets