Generic Name


Therapeutic Category



Cefdinir 125mg Dispersible Tablets

Cefdinir 250mg Dispersible Tablets

Cephalosporin Antibiotic



    Cefdinir binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.


    Absorption: Maximum plasma concentrations occur 2 to 4 hours after an oral dose of Cefdinir.

    Bioavailability: 16% to 21% for the capsules and 25% for the oral suspension

    Distribution: Widely distributed

    Protein binding: 60% to 70% bound to plasma proteins

    Metabolism: Undergoes minimal metabolism

    Excretion: Via renal excretion. Renal dysfunction reduces the clearance of Cefdinir and results in the need to reduce dosing frequency. No dosage adjustment is needed in patients with hepatic impairment

    Half-life: 2.2 ± 0.6 hrs after a 7mg/kg dose and 1.8 ± 0.4 hrs after a 14 mg/kg dose


    Pneumonia, Bronchitis, Otitis Media, Tonsillitis/ Pharyngitis, Sinusitis, Skin & Structure Infection


    The recommended dose for Cefdinir in children is 7mg/kg twice daily or 14mg/kg once daily and for adult is 300mg twice daily for 5-10 days.

    Side effect

    Diarrhea, rash, vomiting, oral thrush, abdominal pain, vaginitis or vaginal moniliasis or leukopenia


    Hypersensitivity to cephalosporin.

    Special Precaution

    Penicillin-sensitive patients; superinfection; seizure; pseudomembranous colitis; pregnancy, lactation; renal or hepatic insufficiency.

    Drug Interaction

    Concomitant admin with antacids and Fe reduce the rate and extent of absorption.

    Probenecid reduces renal elimination.

    Antacids reduce rate and extent of absorption

    Pregnancy Category

    Category B