Generic Name


Therapeutic Category


Cefpodoxime Proxetil

Cefpodoxime Proxetil 200mg Tablets

Cephalosporin Antibiotic


     CEFIME 200  Each film coated tablet contains:
    Cefpodoxime Proxetil            200mg



    Food Interaction:Food delays absorption; cefpodoxime levels may be increased with food.

    Administration: Should be taken with food.

    Pregnancy: Category B

    Storage: Store between 20-25°C

    Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose


    Pharmacotherapeutic Group:Beta lactam Antibiotic


    Pharmacodynamic Properties:CefpodoximeProxetil is third generation oral cephalosporin  with broad activity against gram-positive and gram-negative bacteria showing bactericidal action. It binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by interfering with transpeptidase enzyme, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.


    Pharmacokinetic Properties:

    Absorption: Decreased absorption in conditions of low gastric acidity. Bioavailability: about 50%.Peak plasma time: ≤1 hr

    Distribution: Distributed well into tissues, including lungs and tonsils; penetrates into pleural fluid; Protein bound: 18-23%

    Metabolism:  De-esterified to cefpodoxime in the intestinal lumen.

    Excretion: Half-life: 2-3 hr; prolonged with renal impairment. Urine (80% as unchanged drug) in 24 hr.



    Acute otitis media, pharyngitis and/or tonsillitis, community-acquired pneumonia, acute bacterial exacerbation of chronic bronchitis, acute and/or uncomplicated urethral and cervical gonorrhea, acute and/or uncomplicated ano-rectal infections in women, uncomplicated skin and skin structure infections,acute maxillary sinusitis, uncomplicated urinary tract infections (cystitis).



    UTI and RTI:Adult: 100 mg every 12 hours; Child: 8-10 mg/kg/day in 2 divided doses. Max dose: 400 mg daily.

    Skin Infection:Adult:400 mg every 12 hours; Child: 8-10 mg/kg/day in 2 divided doses. Max dose: 400 mg daily.

    Pharyngitis and/or tonsillitis:Adult:100 mg every 12 hours; Acute community-acquired pneumonia:Adult:200 mg every 12 hours; Uncomplicated gonorrhea (men and women) and rectal gonococcal infections (women): 200 mg single dose

    Acute maxillary sinusitis:Adult: 200 mg every 12 hours

    Uncomplicated urinary tract infection:Adult: 100 mg every 12 hours



    Anaphylactic shock; purpuric nephritis, skin rash, pruritus, diarrhoea, nausea, abdominal pain, vomiting.

    Potentially Fatal: Pseudomembranous colitis, nephrotoxicity.


    History of allergy to penicillin, severe renal impairment, pregnancy and lactation.


    Antacids or H2-blockers may decrease the absorption of cefpodoxime. Probenecid inhibits renal excretion.

    Potentially Fatal: Monitor renal function during administration. Additive nephrotoxic effects with furosemide.


    Patients with a known allergy to cefpodoxime or to the cephalosporin group of antibiotics.




    CEFIME 200: Each box contains 10 Blister of 10 Tablets per strip