Adapalene + Clindamycin
0.1 % w/w Adapalene + 1 % w/w Clindamycin
INDICATION : Acne Vulgaris
MECHANISM OF ACTION : Adapalene binds to specific retinoic acid nuclear receptors of skin and lead to normalization of keratinocyte differentiation allowing for decreased micro-comedone formation, decreases clogging in pores and gives exfoliative properties by increasing cell turnover. Adapalene also shows anti-inflammatory effect by inhibition lipo-oxygenase activity. Clindamycin inhibits protein synthesis of bacteria (P. acnes) which causes infection on the acne lesions, by binding to 50S ribosomal subunit thus kills bacteria.