Generic Name

Composition

Therapeutic Category

Division

Amlodipine + Losartan Potassium

Amlodipine 5mg + Losartan Potassium 50 mg Tablets

Anti-hypertensive

GENESIS

    Indication

    Combination drug used to treat high blood pressure not effectively controlled by monotherapy. 

    Pharmacodynamics

    Amlodipine: Falls under Calcium Channel Blocker. Inhibits the transport of calcium and vascular smooth muscle cells resulting in inhibition of excitation-contraction coupling and subsequent contraction.

    Losartan: Falls under Angiotensin Receptor Blocker.  Blocks the vasoconstrictor and aldosterone-secreting effects of Angiotensin II at various receptor sites, including vascular smooth muscle and the adrenal glands.

    Pharmakokinetic Properties

    Amlodipine

    • Absorption: Well absorbed after oral administration (64-90)%
    • Distribution: Protein Binding is (95-98) % . Crosses the placenta.
    • Metabolism/Excretion: Mostly metabolized by liver
    • Half-Life: 30-50 hr

    Losartan

    • Absorption: Well absorbed but undergoes extensive first-pass hepatic metabolism, resulting in 33 % bioavailability
    • Distribution: Protein Binding 99%. Crosses the placenta
    • Metabolism/Excretion: Undergoes extensive first-pass liver metabolism ,14% is converted to active metabolite.4%excreted unchanged in urine; 6% excreted in urine as active metabolites.
    • Half- Life: 2hrs(6-9 hrs for metabolites).

    Warning & Precaution

    • History of angioedema
    • Heart Failure with or without renal failure
    • Excessive vomiting & Diarrhoea leading to extreme loss of fluid
    • In patient with kidney transplant recently
    • Impaired Liver function

    Children and Adolescents

    Not recommended

    Pregnancy Category :  C

    Breast Feeding : Not recommended