TIME Pharmaceuticals : Touching Lives, Delivering Promises
"स्वस्थ नेपाल हाम्रो अभियान; गुणस्तरीय औषधि हाम्रो पहिचान"
TIME Pharmaceuticals: Thrive For Effectiveness
Generic Name
Composition
Therapeutic Category
Division
Rifaximin
Rifaximin 550 mg Tablets
Rifaximin 200 mg Tablets
Rifamycin Antibiotic
NEXUS
Brand Name: Ribet
Generic: Rifaximin
Composition: Rifaximin 550 mg & 200 mg Tablets
Therapeutic Category: Antibiotic
Mechanism of action:
Hepatic encephalopathy: Inhibits growth of enteric ammonia-producing bacteria to indirectly reduce serum ammonia level
Irritable bowel syndrome with diarrhea: The exact mechanism of action for IBS-D is not known, but is thought to be related to changes in the bacterial content in the gastrointestinal tract and reduction of gas
Pharmacokinetics:
|
Absorption: |
Bioavailability: <0.4%, Peak plasma time: 1 hr |
|
Distribution: |
Gut: 80-90% |
|
Metabolism: |
Induces CYP3A4 in hepatocytes in vitro |
|
Elimination: |
Half-life: 2-5 hr, Excretion: Feces (>90%) |
Indication & Dosing:
|
Indication |
Dosing |
|
Hepatic Encephalopathy in adult |
550 mg twice daily |
|
Traveler’s Diarrhea by noninvasive strains of E. coli (>12 years) |
200 mg thrice daily for 3 days |
|
Irritable Bowel Syndrome with diarrhea (IBS-D) in adult |
550 mg thrice daily for 14 days;recurrence of symptoms can be retreated with the same regimen upto 2 times |
Ribet can be taken with or without food
Pregnancy Category: C
Lactation: Use not recommended
Side Effects: Flatulence, Headache, Rectal tenesmus, Abdominal pain, Defecation urgency
Cautions: Not effective in diarrhea complicated by fever, hematochezia, or diarrhea due to pathogens other than Escherichia coli
Missed Dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Presentation:
