Generic Name

Composition

Therapeutic Category

Division

Terbutaline Sulphate + Bromhexine HCl

(Terbutaline Sulphate 2.5mg+ Bromhexine HCl 8mg) /5ml in 100ml

(Terbutaline Sulphate 1.5mg+ Bromhexine HCl 4mg) /5ml in 60ml

Bronchodilator + Mucolytic

ERRA

    BRAND COMPOSITION DESCRIPTION
    PULMARIN-X

    Each 5ml  contains:

    Terbutaline Sulphate:    2.5 mg

    Bromhexine HCl:           8mg

    100ml Syrup in mixed fruit flavor

    PULMARIN-X Pead.

    Each 5ml  contains:

    Terbutaline Sulphate:    1.5 mg

    Bromhexine HCl:           4mg

    60ml Syrup in mixed fruit flavor

     


    PHARMACOLOGY
     

    Pharmacotherapeutic Group: Cough Preparation (Productive Cough)

    Terbutaline Sulphate: Terbutaline is a bronchodilator; a medication that dilates (expands) air passages in the lungs. It attaches to beta adrenergic receptors on muscles surrounding the air passages, causing the muscles to relax and dilate the air passages. Wider air passages allow more air to flow in and out of the lungs.

    Pharmacokinetics:

    • Protein binding 25%
    • Metabolism GI tract (oral), liver; CYP450: unknown
    • Elimination half-life 11–16 hours
    • Excretion urine 90% (60% unchanged), bile/faeces

    Bromhexine HCl: Bromhexine acts on the mucus at the formative stages in the glands, within the mucus-secreting cells. Bromhexine disrupts the structure of acid mucopolysaccharidefibres in mucoid sputum and produces less viscous mucus, which is easier to expectorate.

    Pharmacokinetics: 

    • Bioavailability 75–80%
    • Elimination half-life 12 hr

     

    INDICATIONS

    Productive Cough associated with Bronchitis, Bronchial asthma, Emphysema, Broncho-Pulmonary disorder

     

    DOSAGE & ADMINISTRATION

    • Drink plenty of fluids while taking PULMARIN-X to loosen mucus.
    • It can be taken with or without food as advised by your doctor with the help of a measuring cup (available at phial).
    • If you use it twice a day, try to leave a gap of 8 to 12 hours between doses.

     

    ADVERSE DRUG REACTIONS

    Nausea, chest pain, vomiting, drowsiness, headache, dizziness, skin rash, tremor, nervousness, diarrhoea and fast heartbeats.

     

    PRECAUTIONS

    PULMARIN-X should be used with caution in patients with allergic on ingredients, epilepsy/seizures, diabetes, high blood pressure, thyroid problems.

     

    CONTRAINDICATIONS

    • Not recommended for children below 6 years of age and body weight less than 25 kg.
    • Not recommended for dry cough (unproductive cough).

     

    PRESENTATION

    • PULMARIN-X: Each bottle 100ml of Syrup
    • PULMARIN-X Pead.: Each bottle 60ml of Syrup

    PATIENT INFORMATION

    Pregnancy Category:   

    ·       Terbutaline: Category C

    ·       Bromhexine: Category A

    Administration:  May be taken with or without food

    Storage: Store at 25 °C

    Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.