PHARMACOLOGY

Pharmacotherapeutic Group: Anticold Oral Drops

Chlorpheniramine Maleate: Chlorpheniramine Maleate is a H₁ receptor antagonist. It binds to the histamine H₁ receptor, blocks the action of histamine which subsequently leads to the temporary relief of the allergic symptoms caused due to histamine.

Pharmacokinetics:

• Bioavailability:25 to 50%
• Protein binding: 72%
• Metabolism: Liver (CYP2D6)
• Elimination half-life: 9–43.4 hours
• Excretion: Kidney

Phenylephrine: Phenylephrine is a sympathomimetic agent. Phenylephrine selectively binds to alpha receptors which cause blood vessels to constrict. 

Pharmacokinetics: 

• Bioavailability: 38% through GI tract
• Protein binding: 95%
• Metabolism: Liver (oxidative deamination)
• Onset of action: within 20 min (by mouth)
• Elimination half-life: 1–3.4 h 

INDICATIONS

Common cold, Sinusitis and Rhinitis, Nasal/Sinus congestion, Sinus pain, Allergy

 DOSAGE & ADMINISTRATION

The usual recommended oral dose of SINEX mini Oral Drops is:

• 1-6 months =0.2 ml thrice or four times a day
• 7-12 months= 0.2-0.4 ml thrice or four times a day
• 1-2 years =0.4-0.8 ml thrice or four times a day

Measure it with a marked dropper and take it as directed by doctor/clinical pharmacist

 ADVERSE DRUG REACTIONS

Sinex mini oral Drops is generally well tolerated and adverse events are rare. Hypersensitive individuals may display ephedrine-like reactions such as tachycardia, palpitations, headache, dizziness and nausea. Use of sympathomimetics has been associated with fear, anxiety, restlessness, tremor, weakness, dysuria, insomnia, hallucinations andconvulsions. Chlorpheniramine in Sinex mini Oral Drops may cause sedation.

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PRECAUTIONS

Sinex mini Oral Drops should be used with caution in patients with renal or hepatic dysfunction, diabetes mellitus, hyperthyroidism, cardiovascular problems, epilepsy and closed angle glaucoma.

CONTRAINDICATIONS

Hypersensitivity to any of the ingredients, severe hypertension

PRESENTATION

SINEX mini Drops : Each duplex contains bottle of 15ml of Syrup with dropper.