PHARMACOLOGY

Pharmacotherapeutic Group: H₁ Antihistamine, 2^nd Generation

Pharmacodynamic properties: EG, is a long-acting, non-sedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H₁ receptors. It has antihistaminic, anti-allergic activity and prevents histamine-induced bronchoconstriction. It has lesser sedative or anti-muscarinic actions.

Pharmacokinetic properties:
EG is rapidly absorbed and undergoes extensive first pass metabolism following oral administration. EG is almost totally converted to the pharmacologically active acid metabolite, carebastine.  Both ebastine and carebastine are highly protein bound (>95%).

 INDICATIONS

 Seasonal allergy, allergic rhinitis, idiopathic chronic urticaria, general allergic conditions

DOSE

Adult: 10mg/20mg once daily.

CONTRAINDICATIONS

Hypersensitivity,cardiac arrhythmias, diarrhea

 SPECIAL PRECAUTIONS

Caution is advised when used in hepatic impairment, renal insufficiency, QTc interval prolongation, pregnancy, lactation.

ADVERSE DRUG REACTIONS

Viral infection (cold/flu); headache, dizziness, drowsiness, fatigue; nausea, dyspepsia, dysmenorrhoea.

 DRUG INTERACTIONS

Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation.

PRESENTATION

Each box is supplied with 10 strips each containing 10 tablets.