PHARMACOLOGY

Pharmacotherapeutic Group: Nutritional supplement

Pharmacodynamic properties: Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Pharmacokinetic properties: 

Absorption: Peak plasma concentrations after 3 hr (oral)

Excretion: Via urine. 

INDICATIONS

Peripheral neuropathy, diabetic neuropathy, hearing impairment, pernicious anemia, alcoholic neuropathy, drug induced neuropathy

 DOSE

Adult: 1500 mcg/day in 3 divided doses.

CONTRAINDICATIONS

Hypersensitivity

ADVERSE DRUG REACTIONS

Anorexia, nausea, vomiting and diarrhea

 DRUG INTERACTIONS

Decreased GI tract absorption with neomycin, aminosalicylic acid, H₂-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol

 PRESENTATION

MECON 500: Each box is supplied with 10 strips of 10 tabs in each.

MECON 1500: Each box is supplied with 10 strips of 10 tabs in each.