Generic Name

Composition

Therapeutic Category

Division

Rabeprazole Sodium

Rabeprazole Sodium 20mg Capsules

Proton Pump Inhibitor

NEXUS

    BRAND COMPOSITION DESCRIPTION

    RABEPRA 20

    Each capsule contains:

    Rabeprazole Sodium BP                      20mg

     RABEPRA 20 contains dark brown colored pellets filled in hard gelatin capsule (size 1) having blue cap & white body.
    PHARMACOLOGY

    Pharmacotherapeutic Group: Proton pump inhibitor (PPI)

    Pharmacodynamic properties: Rabeprazole is a PPI that suppresses gastric acid secretion by inhibiting the gastric H+/K+ ATPase at the secretory surface of the gastric parietal cell. It also promotes the production of gastric mucus.

    Pharmacokinetic properties:

    Absorption: Oral bioavailability: about 52% and peak plasma concentrations are reached about 3.5 hr after oral administration.

    Distribution: Protein binding: 95-98%

    Metabolism: Partially metabolized in the liver by cytochrome P450 isoenzymes.

    Excretion: Metabolites are mainly excreted in the urine (90%). Half-life: about 1-2 hour.

     INDICATIONS

     Gastritis, zollinger ellison syndrome, duodenal ulcer, gastroesophageal reflux disease (GERD), NASIDs induced gastric ulceration, peptic ulcer, acid induced dyspepsia, H. pylori eradication.

    DOSE

    Adult: 20 mg once or twice a day

    PATIENT INFORMATION

    Administration: 

    • May be taken with or without food.

    Food interaction:

    • High fat meals delay the absorption.

    Storage: Store capsules at 15-30 °C

    Missed dose: 

    • Take the missed dose as soon as you remember
    • Skip the missed dose if it is almost time for your next scheduled dose
    • Do not take extra medicine to make up the missed dose.
    CONTRAINDICATIONS

    Hypersensitivity, children less than 12 years

     SPECIAL PRECAUTIONS

    Severe hepatic impairment, gastric malignancy. May increase the risk of GI infections due to acid suppressive effects. Pregnancy.

    ADVERSE DRUG REACTIONS

    Headache, diarrhoea, skin rashes, pruritus, dizziness, fatigue, constipation, nausea, vomiting, flatulence, abdominal pain, arthralgia, myalgia, urticaria, dry mouth

     DRUG INTERACTIONS

    May reduce absorption of ketoconazole and itraconazole. May prolong the elimination of diazepam, phenytoin and warfarin.

     PRESENTATION

    Each box is supplied with 20 strips of 10 caps in each.