PHARMACOLOGY

Pharmacotherapeutic Group:Beta lactam antibiotic

Pharmacodynamic Properties:Cefixime is third generation oral cephalosporin  with broad activity against gram-negative bacteria. It has bactericidal action. It binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by interfering with transpeptidase enzyme, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

 Pharmacokinetic Properties:

Absorption:About 40%-50% absorbed orally

Distribution: Serum protein binding is concentration independent with a bound fraction of approximately 65%.

Metabolism: Not metabolised significantly

Excretion: Mainly via the urine, and small amounts eliminated in bile.

INDICATIONS

Uncomplicated UTI, Uncomplicated Gonorrhoea, Typhoid fever, Acute Bronchitis

DOSAGE & ADMINISTRATION

Adult: 200mg twice daily or400 mg as a single dose. Child (6 month or older): 8 mg/kg/day administered as a single dose or in two divided doses.

ADVERSE DRUG REACTIONS

Diarrhoea, nausea, vomiting, abdominal pain, headache, dizziness, thrombocytopenia, eosinophilia.

Potentially Fatal: Pseudomembranous colitis.

PRECAUTIONS:

History of allergy to penicillins, pregnancy, lactation, renal failure, gastrointestinal disease

DRUG INTERACTIONS

Increased concentrations with probenecid. Increase in plasma levels of carbamazepine when administered concomitantly.

Potentially Fatal: May increase prothrombin time with anticoagulants

CONTRAINDICATIONS

Known allergy to cefixime or other cephalosporins.

PRESENTATION

FIXCEF-100 DT: Each box contains 10 Strips of 10 Tablets

FIXCEF-200 DT: Each box contains 10 Strips of 10 Tablets

FIXCEF-50 DRY SYRUP: Each bottle contains 30ml of dry syrup

FIXCEF-100 DRY SYRUP: Each bottle contains 30ml of dry syrup