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Generic Name
Composition
Therapeutic Category
Division
Albendazole
Albendazole 400mg Tablets
Albendazole 400mg/10ml Suspension
Anti-helmintic
TIME
| BRAND | COMPOSITION | DESCRIPTION |
|---|---|---|
| WORMSTAT TAB | Each tablet contains: Albendazole BP 400mg |
Light pink coloured, oblong uncoated tablet with breakline on one side |
| WORMSTAT SUSPENSION: | Each10 ml contains: Albendazole USP 400mg |
Off white colored flavoured suspension filled in amber coloured glass bottle and sealed with ROPP cap. |
PATIENT INFORMATION |
|---|
|
Food Interaction: Food significantly increases the absorption of albendazole. Administration: Should be taken with food. Pregnancy: Category C Storage: Store tablets between 20-25°C Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose |
PHARMACOLOGY
Pharmacotherapeutic Group:Antihelmentic Drug
Pharmacodynamic Properties:Albendazole sulfoxide (active metabolite), causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larvae; glycogen is depleted, glucose uptake and cholinesterase secretion are impaired and desecretory substances accumulate intracellulary. ATP production decreases, causing energy depletion, immobilisation and worm death.
Pharmacokinetic Properties:
Absorption: Poorly absorbed from the GI tract. Absorption may be enhanced by a fatty meal.Time to peak plasma concentration: 2-5 hr.
Distribution: Widely distributed throughout the body including the bile and Cerebrospinal Fluid (CSF). Plasma protein binding: Approx. 70%
Metabolism: Undergoes extensive hepatic first-pass metabolism; converted to albendazole
Excretion: Mainly via the bile, and small amounts in urine. Plasma half-life: Approximately 8.5 hr.
INDICATIONS
Hydatid disease, neurocysticercosis, ascariasis, hookworm infections, filariasis, cutaneous larva migrans.
DOSAGE & ADMINISTRATION
Enterobiaisis, Ascariasis, Hookworm infections:Adult: 400 mg as a single dose.Child: ≥2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose. Echinococcosis/ Hydatid disease:400mg BD for 4 weeks, repeat after 2 weeks if needed up to three courses
ADVERSE DRUG REACTIONS
Headache, increased intracranial pressure, dizziness, fever, vertigo, meningeal signs, alopecia, abdominal pain, nausea and vomiting, hypersensitivity reactions including rash and urticaria
PRECAUTIONS
Patient with retinal lesions. Patient treated for neurocysticercosis should receive appropriate steroid and anticonvulsant therapy as required. Pregnancy and lactation
DRUG INTERACTIONS
Increased serum concentrations with dexamethasone, praziquintel and cimetidine. Decreased serum concentrations with aminoquinolone (antimalarials), carbamazepine, phenobarbital and phenytoin. Plasma concentration of theophylline be monitered during and after treatment as albendazole induces cytochrome P4501A in human hepatoma cells.
CONTRAINDICATIONS
Patients with hypersensitivity to albendazole or its components; pregnant women
PRESENTATION
WORMSTAT: Each box contains 20 Blister of 1 tablet per strip
WORMSTAT SUSPENSION: Each bottle contains 10ml of suspension
