Fluconazole 150mg Capsules
Each capsule contains:
|Size '2' plain hard Gelatin Capsule with green cap and yellow body filled with white to off white blend of granular powder.|
Administration: May be taken with or without food.
Fluconazole can pass into breast milk and may harm a nursing baby. Do not breast-feed while taking fluconazole.
Storage: Store capsules below 30°C
Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Pharmacotherapeutic Group:Antifungal Agent
Pharmacodynamic Properties:Fluconazole interacts with an enzyme 14 α demethylase necessary to convert lanosterol to ergosterol. Ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular components and thus leading to cell death.
Absorption: Well absorbed after oral administration, Peak plasma concentrations after 1-2 hr(oral), may be increased with multiple dosing
Distribution: Widely distributed. Protein binding: 12%
Excretion: Via urine (80% as unchanged , 11% as metabolites), Elimination half life: 30 hr, increased in renal impairment.
Superficial mucosal candidiasis, Vaginal Candidiasis, Oropharyngeal and Esophageal Candidiasis, Pityriasis Versicolor, Cutaneous candidiasis, Systemic Candidiasis, Cryptococcal infections, prophylaxis of fungal infections in immunocompromised patients
DOSAGE & ADMINISTRATION
Superficial mucosal candidiasis: 50-100mg daily for 7-14 days; Vaginal candidiasis: 150mg single dose; Cutaneous candidiasis: 50mg daily for up to 6 weeks
ADVERSE DRUG REACTIONS
Nausea, abdominal pain, vomiting, diarrhoea, flatulence, elevated liver function values, headache, rashes, exfoliative dermatitis.
Pregnancy, lactation, renal or hepatic impairment, may prolong QT interval
Decreased absorption with concurrent sucralfate, magnesium-aluminum antacids, calcium, iron, zinc and multivitamins. Increased methotrexate and caffeine levels when taken concurrently with ciprofloxacin. Concurrent use with corticosteroids may increase tendon rupture.
Hypersensitivity, co administration of other drugs known to prolong the QT interval and which are metabolized by enzyme CYP3A4 such as cisapride, astemizole, erythromycin, pimozide and quinidine.
FAZOLE: Each box contains 20 Blister of 1 Capsule per strips