Dextromethorphan +Chlorpheniramine + Phenylephrine
Dextromethorphan 15mg+Chlorpheniramine Maleate 1mg + Phenylephrine HCl 5mg
Each 5ml syrup contains:
Chlorpheniramine Maleate 1mg
Phenylephrine HCl 5mg
Pharmacotherapeutic Group: Anticough Preparation
Chlorpheniramine Maleate is a H1 receptor antagonist. It binds to the histamine H1 receptor, blocks the action of histamine which subsequently leads to the temporary relief of the allergic symptoms caused due to histamine.
Chlorpheniramine is absorbed relatively slowly from the GI tract and widely distributed. Almost 70% of the drug binds to the plasma protein. It undergoes extensive metabolism and converted to desmethyl and didesmethyl chlorpheniramine. Both the unchanged drug and the metabolites are excreted via urine.
An oral sympathomimetic amine that acts as a decongestant to respiratory tract mucous membranes. While its vasoconstrictor action is similar to that of ephedrine, phenylephrine has less pressor effect in normotensive adults.
Serum half-life for phenylephrine is 6 to 8 hours. Acidic urine is associated with faster elimination of the drug. About one-half of the administered dose is excreted in the urine.
A non-narcotic antitussive with effectiveness equal to codeine. It acts in the medulla oblongata to elevate the cough threshold. Dextromethorphan does not produce analgesia or induce tolerance, and has no potential for addiction. At usual doses, it will not depress respiration or inhibit ciliary activity.
Dextromethorphan is rapidly metabolized with trace amounts of the parent compound in blood and urine. About one-half of the administered dose is excreted in the urine as conjugated metabolites
For relief of coughs and upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold.
DOSAGE & ADMINISTRATION
Three times daily or as required.
ADVERSE DRUG REACTIONS
Sedation, drowsiness, dizziness, GI upsets, anorexia or increased appetite, epigastric pain, blurring of vision, dysuria, dryness of mouth, hypertension, shortness of breathe.
Hypertension, heart disease, asthma, hyperthyroidism, increased intraocular pressure, diabetes mellitus 1 and prostatic hypertrophy
Hypersensitivity to any of the ingredients
PULMARIN: Each bottle contains 100ml of Cough syrup
Storage: Store at 25 °C
Pregnancy: Category C
Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.