Generic Name
Composition
Therapeutic Category
Division
Cloxacillin
Cloxacillin 500mg Capsules
Penicillin Antibiotic
COSMO
BRAND | COMPOSITION | DESCRIPTION |
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TICLOX |
Each capsule contains: Cloxacillin Sodium BP eq. to Cloxacillin 500mg |
White to slightly yellowish blend filled in '0' size plain hard gelatin capsule shell having yellow body and green cap. |
PATIENT INFORMATION |
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Administration:
Food interaction: Delayed absorption in the presence of food; Do not drink juice or carbonated beverage (soda) with TICLOX as it will decrease the effectiveness of the drug; Alcohol may irritate the stomach if taken with TICLOX. Pregnancy: Category B Nursing Mother: It is not known whether TICLOX passes into breast milk. Storage: Store in dry place below 25°C; Keep out of reach of children. Missed dose: Take the missed dose as soon as you remember; Skip the missed dose if it is almost time for your next scheduled dose; Do not take extra medicine to make up the missed dose.
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PHARMACOLOGY
Pharmacotherapeutic Group: β-lactam antibiotic; Penicillin
Pharmacodynamic properties: TICLOX (Cloxacillin) binds to penicillin-binding protein (PBPs) and inhibits the transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly. This causes formation of a defective cell wall that is osmotically unstable, resulting in bacterial cell death.
Pharmacokinetic properties:
Absorption: Incompletely absorbed from the GI tract with peak plasma concentrations after 1-2 hr; Oral bioavailability: 50%
Distribution: Pleural and synovial fluids and bone (therapeutic concentrations), CSF (small amounts except when the meninges are inflamed; crosses the placenta and enters breast milk. Protein-binding: 94%
Metabolism: Minimal metabolism.
Excretion: Via the urine by glomerular filtration and renal tubular secretion (35% of an oral dose); via the bile (Up to 10%). Not removed by dialysis; Elimination half-life: 0.5-1 hr.
DOSE
250-500mg 4 times daily.
CONTRAINDICATIONS
Hypersensitivity to penicillins.
SPECIAL PRECAUTIONS
Renal impairment; Pregnancy and lactation; Porphyria; Cephalosporin hypersensitivity.
ADVERSE DRUG REACTIONS
Neutropenia, agranulocytosis; GI upsets; rash. Sore mouth or tongue; Black hairy tongue. Potentially Fatal: Neuromuscular hypersensitivity; pseudomembranous colitis; anaphylaxis.
DRUG INTERACTIONS
Coadministration of probenecid or disulfiram may result in higher cloxacillin concentration; Chloramphenicol and tetracycline antagonise bactericidal effect of penicillins; Cloxacillin increases the effect of methotrexate and side effect of allopurinol (may cause rashes); Cloxacillin may decrease the effectiveness of birth control pills.
Potentially Fatal: Increased hypoprothrombinaemic effects of oral anticoagulants.
PRESENTATION
TICLOX: Each box contains 10 strip packs of 10 capsules per strip.