Generic Name

Composition

Therapeutic Category

Division

Clotrimazole + Lidocaine + Chloramphenicol

Clotrimazole1% w/v+ Lidocaine 2% w/v+ Chloramphenicol 5% w/v Ear Drops

Anti-infective

COSMO

BRAND	COMPOSITION	DESCRIPTION
CLOTIME LC	Clotrimazole IP 1% w/v Lidocaine Hydrochloride BP 2% w/v Chloramphenicol IP 5% w/v	Clear colourless solution filled in a 13.2 ml overflow capacity gamma sterilized Lupolene vials plugged with gamma sterilized inner seal and capped with gamma sterilized caps.

BRAND

COMPOSITION

DESCRIPTION

CLOTIME LC

Clotrimazole IP 1% w/v

Lidocaine Hydrochloride BP 2% w/v

Chloramphenicol IP 5% w/v

Clear colourless solution filled in a 13.2 ml overflow capacity gamma sterilized Lupolene vials plugged with gamma sterilized inner seal and capped with gamma sterilized caps.

PATIENT INFORMATION
Administration: Use the ear drops as directed in the label. Do not apply it to the eyes and never administer it by mouth. If you suffer from an opening of the ear drum, tell your physician, as increased side effects may occur in patients with this condition. Use the ear drop within one month after opening the container. Do not use if the solution contains particles/suspended matter. Storage: Store below 25°C in a cool, dry place; Protect from light and moisture; Keep out of reach of children. Missed dose: Take the missed dose as soon as you remember; Skip the missed dose if it is almost time for your next scheduled dose; Do not take extra medicine to make up the missed dose.

PATIENT INFORMATION

Administration:

Use the ear drops as directed in the label.
Do not apply it to the eyes and never administer it by mouth.
If you suffer from an opening of the ear drum, tell your physician, as increased side effects may occur in patients with this condition.
Use the ear drop within one month after opening the container.
Do not use if the solution contains particles/suspended matter.

Storage: Store below 25°C in a cool, dry place; Protect from light and moisture; Keep out of reach of children.

Missed dose: Take the missed dose as soon as you remember; Skip the missed dose if it is almost time for your next scheduled dose; Do not take extra medicine to make up the missed dose.

PHARMACOLOGY

Clotrimazole: Clotrimazole is a synthetic imidazole derivative. Clotrimazole acts against fungi by inhibiting 14α demethylase enzyme thus prevent the conversion of lanosterol to ergosterol. Inhibition of ergosterol synthesis therefore, leads to structural and functional impairment of the fungal cytoplasmic membrane.

Lidocaine: Lidocaine (Lignocaine) is commonly applied topically for its strong local anesthetic properties. It has been proven to reduce pain in the auditory canal in patients affected by acute ear infections. Lidocaine alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation.

Chloramphenicol: Chloramphenicol is a broad-spectrum antibiotic. It is bacteriostatic but may be bactericidal in high concentrations or when used against highly susceptible organisms. Chloramphenicol stops bacterial growth by reversibly binding of the 50S subunit of bacterial ribosomes leading to suppression of peptidyltransferase activity (where transfer of amino acids to growing peptide chains is prevented) thus inhibiting peptide bond formation and subsequent protein synthesis.

INDICATIONS

Otomycosis; Otitis externa: Acute otitis media; Chronic suppurative otitis media

DOSE

Instill 4 to 5 drops into the affected ear 3 to 4 times daily.

CONTRAINDICATIONS

Hypersensitivity

ADVERSE DRUG REACTIONS

Common side effects such as itching or burning sensations in the ears may occur. Consult your physician immediately if any of these side effects persist or worsen, or if you notice any unusual symptoms after applying these ear drops.

PRESENTATION

Each vial contains 10ml of solution

PRODUCT DETAILS

Product Lists

CLOTIME LC

Description & Professionals

CLOTIME LC

PATIENT INFORMATION