TIME Pharmaceuticals : Touching Lives, Delivering Promises
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TIME Pharmaceuticals: Thrive For Effectiveness
Generic Name
Composition
Therapeutic Category
Division
Atrovastatin
Atorvastatin 5 mg Tablet
Atorvastatin 10 mg Tablet
Atorvastatin 20 mg Tablet
Hypolipidemic
GENESIS
| BRAND | COMPOSITION | DESCRIPTION |
|---|---|---|
| LIPLOW 5 |
Each film coated tablet contains:
Atorvastatin Calcium IP 5mg
|
Light Orange coloured, biconvex, film-coated tablet with smooth surface on both sides |
| LIPLOW10 |
Each film coated tablet contains:
Atorvastatin Calcium IP
|
Light orange coloured, round, biconvex, film coated tablet with 10 embossed on one side |
| LIPLOW20 |
Each film coated tablet contains:
Atorvastatin Calcium IP 20mg
|
Pink colored, round film coated tablet with breakline on one side |
Pharmacotherapeutic Group: Lipid lowering agents
Pharmacodynamic properties: Atorvastatin is a member of the drug class known as statins, used for lowering blood cholesterol.Atorvastatin competitively inhibits HMG-CoA reductase, the enzyme that catalyses the conversion of HMG-CoA to mevalonic acid. This results in the induction of the LDL receptors, leading to lowered LDL-cholesterol concentration.
Pharmacokinetic properties:
Absorption: Rapid from the GI tract (oral); Distribution: Protein-binding: 98%; Metabolism: Extensively hepatic; converted to active inhibitors of HMG-CoA reductase; Excretion: Faeces (as metabolites); 14 hours (elimination half-life).
INDICATIONS : Prevention of Cardiovascular Disease, Primary hypercholesterolemia, Elevated serum TG levels
DOSE :The recommended starting dose is 10 or 20 mg once daily
PATIENT INFORMATION |
|---|
|
Administration
Pregnancy Category: X Storage: Store below 25 °C Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. |
CONTRAINDICATIONS Hypersensitivity
SPECIAL PRECAUTIONS Patients who consume substantial quantities of alcohol. History of liver disease. Patients with risk factors for myopathy or rhabdomyolysis. Hypothyroidism should be properly managed prior to starting statin therapy. Children
ADVERSE DRUG REACTIONS Headache, flatulence, diarrhoea, nausea, vomiting, anorexia, xerostomia, angioedema, myalgia, rash/pruritus, alopecia, allergy, infection, chest pain.Potentially Fatal: Thrombocytopenia. Rhabdomyolysis with acute renal failure.
DRUG INTERACTIONS : Increased AUC for norethindrone and ethinyl estradiol. Concomitant multiple doses of atorvastatin and digoxin increased steady-state digoxin levels. Increased risk of rhabdomyolysis when used concurently with fibrates. Co-admin with antacid suspensions and colestipol decreased atorvastatin levels.
